* Calculated by Panasonic
■ Opinion from Professor Masafumi Mukamoto of Osaka Prefecture University about the results of verification:
The novel coronavirus binds to host cells through a spike protein that exposes outward, enters the cells, and then propagates. Some antibodies, such as neutralizing antibodies produced by vaccination or infection, bind to the spike protein thereby preventing the virus from binding to host cells, hence the propagation of virus and pathogenesis are inhibited. Viruses, on the other hand, make incorrect copies of viral genes as they multiply in cells. This is called mutation. In particular, a virus with mutation in amino acid of spike protein, as a variant, increases its binding capacity to cells and makes it difficult for it to bind to neutralizing antibodies, causing a resurgence of COVID-19.
Although the antiviral effect of the hydroxyl radicals contained in water is not completely understood, but it is not a highly specific reaction (the property that an antibody reacts only with a specific antigen) like an antibody. In fact, based on the results of this verification, there was no difference in the inhibition rate of hydroxyl radicals contained in water among the novel coronavirus variants. Therefore, it is considered that viral mutations caused by some amino acid substitutions do not affect the inactivation effect.
Accordingly, it is expected that the "Hydroxyl radicals contained in water" technology will produce the same experimental results when tested under the same experimental conditions as this time for mutants that are expected to appear in the future.
*1: The Japan Textile Quality Technology Center (QTEC) was established in 1993, which is a testing and evaluation institute for antibacterial and antiviral testing to meet the needs of society. It is an organization with the technology to meet the various test methods defined by JIS, ISO, AATCC, ASTM, GB, KC, standards of inspection organizations, standards of companies such as department stores and mass merchandisers, standards of government agencies, QTEC standards, etc.
*2: Main releases on verification cases
- May 12, 2009：Positive effects of charged water particles on viruses, bacteria, and agricultural chemicals have been verified.
- October 20, 2009： The new influenza virus inhibition effect of charged water particles has been verified.
- February 20, 2012：Supression effect of charged water particles on pet-related allergens, bacteria, fungi, and viruses have been verified.
- January 16, 2014：Nano-sized electrostatic atomized water particles effectively breaks down PM2.5 components and inhibits growth of fungi attached to Yellow Sand.
*3 Verified jointly with Osaka Prefecture University
*4: January 26, 2012: Virus suppression effect of charged water particles has been verified by the virus clearance test. Co-verified with Charles River Biopharmaceutical Services GmbH, a German testing organization.
*5: nanoe™ X Generator Mark 2 generates 9.6 trillion hydroxyl radicals per second, a 20-fold volume compared with that of nanoe™.